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In vitro optimization of formulation technology: the "nano revolution" of insoluble drugs Tadalafil is a poorly soluble drug (with solubility below 250 mL/20 mg in the pH range of 1.0-7.5), and its oral bioavailability is only 36%

Liposomal glutathione encases the glutathione molecule in a lipid (fat) layer that protects it through the digestive process and improves delivery into the bloodstream and cells

The molecule is small, cheap to synthesise, and would be difficult to defend commercially

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Data on hepatic fibrosis are limited or inconclusive, although some studies reported improvement in indices of fibrosis or prevention of fibrosis initiation or reduction of collagen deposition

Scenario 2: Increasing from 0.5mg to 1mg You have been on 0.5mg for four weeks with tolerable side effects