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While TDD systems have demonstrated promising outcomes, scaling up, translating preclinical research into clinical success, and obtaining regulatory approval remain difficulties for commercial success

(2012) described a lack of relation between the loss of striatal dopaminergic function, assessed by positron emission tomography (PET), and CSF -synuclein levels, in asymptomatic carriers of mutations in the LRRK2 gene

Acknowledgements The authors thank technical supports provided by the Instrument and Equipment Sharing Center of College of Life Sciences of Wuhan University

During the week before the experiments began, all mice were housed under conventional conditions and fed a standard diet and water ad libitum at the animal facility (Research Resource Facility)

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2 Main text The class of DPP-4 inhibitors has grasped a lot of attention in the recent years