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For instance, upon recognizing LPS from Gram-negative bacteria, TLR4 activates NF-B and MAPK signaling via the MyD88-dependent pathway, inducing the release of pro-inflammatory cytokines such as IL-6 and TNF-to clear pathogens in the intestine or lungs (143, 144);Meanwhile, the TLR2/6 heterodimer recognizes bacterial toxins, promoting Th17 cell differentiation to enhance immune responses (145)

Nature 508 (7495), 258262

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& Lisonkova, S