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Moreover, activated CD8 + T cells secreted interferon (IFN-), which inhibits GPX4 and other GSH-dependent enzymes, leading to ferroptosis in cancer cells [36]

Regulatory pathways for damaged mitochondria Clearance and prevention of abnormal protein aggregation or damaged protein accumulation create the first barrier of mitochondrial quality control

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Racemic mixture versus R-lipoic acid only R -lipoic acid is the isomer that is synthesized by plants and animals and functions as a cofactor for mitochondrial enzymes in its protein-bound form (see Biological Activities)

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aqueous extract: potential nanoshuttles for brain-delivery of phenolic compounds