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STEP-1 Trial (Semaglutide 2.4 mg, N=1,961) The STEP-1 trial published in the New England Journal of Medicine reported that among participants receiving semaglutide 2.4 mg subcutaneously once weekly, nausea occurred in 44.2%, diarrhea in 29.7%, vomiting in 24.5%, and constipation in 24.1%, compared to 16.0%, 15.9%, 6.8%, and 11.1% with placebo, respectively [3]

To our knowledge, this is one of the first prospective case-control studies focusing exclusively on female FM patients

Many experiencing nausea describe it as mild background queasiness rather than debilitating sickness

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Patients and prescribers may still see intermittent localized supply disruptions as the products move through the supply chain from the manufacturer and distributors to local pharmacies

While school districts and childcare issues can sometimes be a factor (for both young and old), the reliability factor generally tilts heavily toward the mature worker