Of note, wild-type TrB showed intermediate levels of Gclc mRNA compared to FoB and in MZB (Supplementary Fig
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In rodent and cell work, NNMT knockdown or inhibition has been described as protecting against diet-induced weight gain and improving metabolic measures without reducing food intake [5] [6]
However, using variants that do not dimerize, it has been recently described that homodimer formation of GCL is not required for enzyme activation (Yang et al., 2019)
