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doi: 10.1158/0008-5472.CAN-05-2754
Cancer cells may metabolize glutamate to -ketoglutarate through one of two different pathways (glutamate dehydrogenase or aminotransferases), with aminotransferases potentially supporting a more biosynthetic and pro-growth phenotype
pennellii (Lpa) (Mittova et al., 2000)
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Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer
This decrease in DHEA and initial rise in cortisol leads to an elevated cortisol/DHEA ratio, which in turn leads to very harmful consequences such as (2): Lower insulin sensitivity with increased blood sugar leading to diabetes
