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Controlled and continuous release ocular drug delivery systems: pros and cons

Further analysis indicated that the wounds exposed to the peptide might have exhibited increased levels of glutathione and ascorbic acid

Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects

Many antioxidant molecules, such as GSH and N-acetylcysteine (NAC), were found to inhibit viral replication through different mechanisms of action (Fraternale et al., 2006)

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Recordings were obtained using a Multiclamp 700B amplifier (Molecular Devices, Sunnyvale, CA), Analog signals were low-pass Bessel filtered at 2 kHz, digitized at 10 kHz through a Digidata 144 OA interface (Molecular Devices), and stored in a computer using Clampex 10.2 software (Molecular Devices)