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When calories drop whether intentionally or because youre simply less hungry your body has to decide where to pull energy from

J Cell Biol

& Hoppe, B

Horm Metab Res 27:372375 Slavin BG, Ong JM, Kern PA (1994) Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes

Even in aggressive scenarios for reduced consumption related to GLP-1 use, modest gains to life expectancy can more than offset the impact over time. Indeed, because obesity-related diseases cut years off average lifespans, treatment with GLP-1 drugs can add years (up to 14 years) to the lives of those who take them

43,44 A study evaluating insulin secretion after oral glucose tolerance testing showed increased insulin levels in patients with HS compared to controls ( P =.02), with 60% (6/10) of patients with HS meeting criteria for insulin resistance