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For example, we observed that both GLP-1 and its presumed inert metabolite GLP-1(936) showed coronary and mesenteric artery vasodilation, as well as cardioprotection from IRI ex vivo, in isolated tissues from both WT and Glp1r -KO ( Glp1r / ) mice, whereas the nondegradable GLP-1R agonist exenatide did not have these effects in the absence of a functional GLP-1R (4, 21)
This is not just a pricing difference - it reflects fundamentally different regulatory pathways
Even when a peptide seems beneficial, cycling allows the body to respond and minimizes potential risks
It also fits Lillys broader access playbook
Most individuals adapt well to tirzepatide when dosing is increased slowly, and side effects tend to diminish after the first few dose escalations
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