J., Schoonover, K
7 Pharmacists should be diligent in staying up to date with emerging benefits of GLP-1 RAs, especially in new indications such as PD, and follow releases of new clinical data that more confidently highlight the role of GLP-1 RAs in PD
Phenotypic Screening Deconvolution After a phenotypic screen identifies active compounds, metabolic fingerprinting provides the first mechanistic triage layer separating compounds that act through energy metabolism, membrane disruption, nucleotide biosynthesis, or signalling pathway inhibition without requiring individual target binding assays
Concentrations of l-carnitine, BB, and TMA were determined by stable isotope dilution LC-MS/MS
Poor pharmacokinetic properties are a leading cause of failure in the drug development process (Page et al., 2016)
Sulfa antibiotics, such as sulfamethoxazole and sulfisoxazole, are commonly used to treat bacterial infections