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doi: 10.1124/jpet.118.254821 63 TonneijckL.MuskietM

Research suggests that AMP-activated protein kinase (AMPK) plays a crucial role in doxorubicin-induced cardiotoxicity

ACS Nano 7 , 30363044 (2013)

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[13] [14] In 2023, it was the 209th most commonly prescribed medication in the United States, with more than 2 million prescriptions

Approved uses are not interchangeable Across the class, FDA-approved indications include type 2 diabetes for most compounds, chronic weight management for Wegovy, Saxenda, and Zepbound, cardiovascular risk reduction in type 2 diabetes for several products, and obstructive sleep apnea in adults with obesity for Zepbound as of 2024