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In 2019 the World Health Organization (WHO) found that 99% of the world population live in places where WHO air quality guidelines are not met, and caused an estimated 4.2 million premature deaths worldwide resulted from ambient air pollution, with low-and middle-income countries accounting for 89% of the estimated deaths [2]

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RNAseq analysis of patient-matched primary and lymph node-metastatic melanoma (LN-met) cells treated with ESI-09 revealed that TXNIP, a regulator of cellular oxidative stress, as a critical gene regulated by EPAC

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Concurrently, drug development efforts will benefit from atomic-resolution insights into competitive antagonism, allosteric modulation, and ion channel block