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Shortly after our publication, very much to our surprise, R254X was also found in 3 different countries as far as in Western Asia and Middle East.13-16 The research team in Lebanon followed our protocol and showed that R254X in Lebanon patients had the same haplotype as ours

The topical use of AKE improved all clinical dry eye symptoms in a dose-dependent manner by promoting the generation of tear fluid and mucin, while demonstrating a favorable safety profile for topical usage [91]

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PMID: 101 ZhaoJ-FLiB-XZhangQ