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Tirzepatide has shown robust improvements in blood pressure and fasting lipid levels

Key players today include Mounjaro (tirzepatide) a dual-agonist of GLP-1 and GIP receptors and coming soon, Retatrutide a triple-receptor agonist (GLP-1, GIP and glucagon) that has shown even stronger early results

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GIPR (glucose-dependent insulinotropic polypeptide) At 1 mg, the GIP signal is already about twice the peak produced by a large meal in obese individuals, and it persists instead of fading. Metabolically healthy bodies respond more strongly

The parallel is not exact, but it provides a plausible biological explanation for why some patients experience reduced sexual desire on GLP-1 therapy