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Most patients experience initial weight loss at 0.5mg, typically losing 24 pounds in the first month
In contrast, SGLT2 inhibitors, although effective for glycemic and cardiovascular risk reduction, 23 promote renal excretion of glucose and sodium, potentially leading to mild systemic dehydration and reduced tear production
When produced excessively, it may suppress the release of Thyroid Stimulating Hormone from the pituitary. 18 It also forces T4 to be converted to reverse T3 (rT3) which actually blocks thyroid function, even though thyroxine levels look adequate when tested. 19 Blood glucose imbalance also triggers cortisol secretion, and insulin resistance may have a direct negative effect on the thyroid, too
Consistency matters more than switching to a 'stronger' medication you cannot tolerate
E.DonahueL