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The combination activates optimal T cell anti-tumor function mediated by CD226, relieving TIGIT and PD-1-mediated T cell inhibition, and further enhancing T cell anti-tumor activity [185]

Aspartate rescues S-phase arrest caused by suppression of glutamine utilization in KRas-driven cancer cells

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Additionally, by improving insulin resistance and adipose-driven inflammation, GLP-1 agonists may reduce metabolic contributors that further perpetuate HS activity

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