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Under the Inflation Reduction Act, Medicare has gained the ability to negotiate prices for high-cost drugs

A primary concern in the initial evaluation is the identification or exclusion of adrenal insufficiency, as it represents the only clinical scenario necessitating immediate, life-saving hormone replacement therapy [147]

J Neurochem2004 Mar;88(5):1203-10

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Conversely, in diseases driven by protein misfolding and toxic substance accumulation (such as certain neurodegenerative diseases and CKD, and PCOS), enhancing LONP1 activity demonstrates significant therapeutic value

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