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In PD, the two forms of MAO, MAO-A, and MAO-B, have been implicated in the pathogenesis of the condition

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance