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5.8 Limited pharmacokinetics and real-world evidence of combination therapy Pharmacokinetic (PK) and pharmacodynamic (PD) studies are needed to determine how combination treatments such as probiotics, vitamin D, and 6-gingerol interact together in the body to impact both efficacy and safety for treating SLE (233)

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J Cell Biochem 104:13561363 Kawanishi N, Sugimoto T, Shibata J, Nakamura K, Masutani K, Ikuta M, Hirai H (2006) Structure-based drug design of a highly potent CDK1, 2, 4, 6 inhibitor with novel macrocyclic quinoxalin-2-one structure

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