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Travica N, Ried K, Sali A, Scholey A, Hudson I, Pipingas A

MiR-142 affects the janus kinase-signal transducer and activator of transcription pathway (JAK-STAT), impairing regulatory T-cell (Treg) function and enhancing autoreactive T-cell activation, contributing to immune dysregulation in HT

Additionally, more compounds make it harder to isolate which one is responsible for any observed benefit (or harm)

Dysregulated macrophage polarization is pivotal in RA pathogenesis

The second is pharmacological: what side effects, treatment burden, and long-term trade-offs come with using medication to push levels that low

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