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In summary, GLP-1R is not merely a metabolic receptor but a central signaling hub with extensive crosstalk across cAMP/PKA, PI3K/Akt, ERK, AMPK, Wnt/-catenin, and NF-B pathways, orchestrating multi-organ protection in metabolic, cardiovascular, and neurodegenerative diseases

As a peptide substance, it is highly sensitive to temperature, humidity, and proteases in the gastrointestinal tract

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A decrease in acetylcholinesterase activity was also observed with risperidone (0.5 mg/kg, i.p.) at 0.08 0.00