Specific effects depend on dose, format, individual factors, and concurrent interventions
Think of it the way the United Ostomy Associations of America describes barrier fit -- like buying shoes
Within seconds of the sensing of increased reactive oxygen species (ROS), several enzymes of glycolysis (particularly glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase) are inhibiting allowing for the diversion of glucose carbons into the PPP
Gastrointestinal effects and referred pain: The pronounced gastrointestinal side effects of GLP-1 therapyparticularly nausea, constipation, and abdominal distensioncan occasionally manifest as referred pain to the back
NovoCare and LillyDirect are available to anyone who doesnt have commercial insurance coverage for the specific drug
Generally, you should continue established IBS therapies including antispasmodics, fiber supplements, and probiotics unless side effects become problematic