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Ethics statement All experimental animals received proper care, and all procedures were conducted in accordance with the guidelines of the National Institutes of Health for the care and use of laboratory animals

A study using a technique known as heterochronic parabiosis where the circulation of a young animal is infused into an older animal, demonstrated improvements in remyelination in the old animal which is presumably due to better functioning of young circulating monocytes for myelin debris clearance (Miron and Franklin, 2014)

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doi: 10.3899/jrheum.180855 23 van FurthRCohnZA

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doi: 10.13703/j.0255-2930.2019.06.018, 232 YangH.XieY.YuJ.ShiM.LiY.CaiY.et al