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Your body typically creates both cyclic guanosine monophosphate (cGMP) and phosphodiesterase-5 (PDE5) in regular balance.6 When you get aroused, your body produces extra cGMP, which results in a relaxation of the muscles that control blood vessel constriction, especially in the penis

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206479489 10.1007/s00213-009-1625-1 Psychopharmacology (Berl.) 62 PullI.McIlwainH

Three studies lasted 12 weeks, five studies lasted 24 weeks, and one study lasted 16 weeks