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Direct binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric coupling between the Binding site and the NBD1:CL4 Interface s

Commonly used in non-clinical research to track changes in tissue-response markers, barrier integrity, and signaling readouts over time (in-vitro and animal models)

Stacking these peptides is a common research approach for synergistic tissue repair support

Protein structure prediction from sequence variation

This research was supported by NIH grant RO1 CA105437 (C.M.U.) and NSF grant DMS-0616710 (M.C.R.)