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Wadden and colleagues assessed changes in depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and suicidal ideation or behaviors using the Columbia Suicide Severity Rating Scale in participants with overweight or obesity using semaglutide 2.4 mg or placebo

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The phase 3 ATTAIN-1 trial compared results for 3127 adult participants with obesity, or who were overweight with a weight-related medical problem, and who did not have diabetes

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Patients were at least 1 year after their primary MBS and had experienced less than 20% weight loss