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doi:10.1097/AOG.0b013e3182267f2f

Because of this, many patients stay on it long-term

174,175 Several oncogenic mechanisms, such as the transcription factor HIF-1, PI3K/Akt/mTOR pathway and c-Myc, upregulate genes encoding glucose transporters and glycolytic proteins, including GLUT1, GLUT3, and lactate dehydrogenase (LDH)

This means pigmentation effects accumulate over days, not hours

To minimize gastrointestinal side effects, doses are gradually increased over several weeks to months

These chemicals may impede ferroptosis, an iron-dependent mode of cellular demise, and provide tailored treatment by scavenging reactive oxygen species and averting lipid peroxidation in tumour microenvironments