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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive adults with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial

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In DIO mice, Vutiglabridin co-administration eliminated GLP-1 RA weight-loss plateaus, synergistically enhancing anti-obesity efficacy and enabling normal body composition beyond appetite suppression limits alone

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