The intracellular carnitine homeostasis and distribution are controlled by the novel organic cation transporter (OCTN) among which OCTN2 is the most important
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In VISTA (n=310), adults with obesity or overweight and at least one comorbidity receiving elecoglipron (75mg) achieved a clinically meaningful and statistically significant average reduction in body weight of 10.5% at 26 weeks compared to 0.6% with placebo, a dual primary endpoint
Li-Huei Tsais group found that cells carrying the variant run their phospholipid pathway poorly and extra choline reversed the defect, a low-risk and mechanism-based option for carriers even though the targeted human trials are not yet in
