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Incretin-based medications, including GLP-1 receptor agonists like semaglutide (Wegovy) and the dual GIP/GLP-1 receptor agonist tirzepatide (Zepbound), promote weight loss through multiple mechanisms that influence body fat distribution

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It increases the Bcl-2/Bax ratio and decreases Bax and cleaved-caspase-3 protein levels, which in turn promotes skeletal muscle autophagy and mitophagy, inhibits apoptosis, and improves the functional status of skeletal muscle mitochondria and skeletal muscle atrophy (Marshall et al., 2022)

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