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They found that semaglutide (Ozempic, Rybelsus, Wegovy) did not reduce oral contraceptive concentrations in blood or significantly delay absorption

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These improvements suggest enhanced liver synthetic capacity and more efficient waste elimination, both critical for maintaining optimal health

In one trial, women randomized to receive either Exenatide or Metformin, followed by Metformin alone, achieved a natural pregnancy rate over twice as high in the exenatide group compared to the metformin group (43.60% vs 18.70%) (108)

An analysis of covariance confirmed that BMI reduction had no effect on headache frequency, strengthening the hypothesis that pressure modulation, not weight loss, drives the benefit