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The innate immune system is an important host defense against pathogens (viruses, bacteria, fungi, and parasites), is also involved in the pathogenesis of various non-infectious inflammatory diseases, and depends, at least in part, on pattern recognition receptor (PRR) activation by pathogen associated molecular patterns (PAMPs) 13

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Individually, the evidence base is strong

these iron-containing structures serve as cofactors for numerous enzymes [1,2,3]