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Plant Cell Environ 38(2):266279

Jacques, F., Rippa, S

Empagliflozin did not increase the incidence of tumors in female rats dosed at 100, 300, or 700 mg/kg/day (up to 72 times the exposure from the maximum clinical dose of 25 mg)

Average weight loss at 72 weeks was 12.8% with 10 mg and 14.7% with 15 mg tirzepatide, compared to 3.2% with placebo

Thus, the distinctive nutritional needs associated with a disease reflect the total amount needed by a healthy person to support life or maintain homeostasis, adjusted for the distinctive changes in the nutritional needs of the patient as a result of the effects of the disease process on absorption, metabolism, and excretion. It was also proposed that in patients with certain disease states who respond to nutritional therapies, a physiologic deficiency of the nutrient is assumed to exist

Clin Genet 2014