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(2) DHODH: DHODH is a mitochondrial flavoprotein localized to the inner mitochondrial membrane, where it catalyzes the fourth and rate-limiting step of de novo pyrimidine biosynthesisthe oxidation of dihydroorotate to orotate 42,43

The SP@M treatment led to a significant decrease in the fluorescence intensity of CD86 (the phenotypic marker of M1-like macrophages) and an increase in the intensity of CD206 (the phenotypic marker of M2-like macrophages), indicating the remission of pro-inflammatory microenvironment (Supplementary Fig

Their advantages include micrometre-scale dimensions, facilitating integration onto flexible substrates to conform to joint surfaces

Mitochondria are bi-membrane organelles central to energy production, cell metabolism, and cell death and regeneration, also serving as primary generators of ROS [52]

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