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At least 5% of ASD cases are caused by single nucleotide polymorphisms (SNPs) in genes such as NLGN3, NLGN4, NRXN1, MECP2, SHANK3, FMR1, and UBE3A, with about 10% of these variants being copy number variations (CNVs) that disrupt protein-coding sequences (6163)

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