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Concurrently, neuromodulators like dopamine, serotonin, and norepinephrine fine-tune taste sensitivity at both peripheral (taste buds) and central (reward circuitry) levels, linking chemosensation to motivational states
2 In addition to lifestyle modifications (diet and exercise), many pharmacologic strategies have been proposed to counter iatrogenic weight gain, including appetite suppressants (eg, pro-dopaminergic agents such as phentermine, stimulants, and amantadine), pro-anorectant anticonvulsants (eg, topiramate or zonisamide), opioid receptor antagonists (eg, olanzapine/samidorphan or naltrexone) and oral hypoglycemics such as metformin
Avoid carbonated drinks and straws, which introduce air into an already sluggish system
Medicare explicitly excludes coverage for weight-loss medications (unless there are associated cardiovascular risks)
But retatrutide appeared to go further
If you are on Medicaid and want GLP-1 for weight loss, check your state's current formulary and ask your prescriber about the diabetes indication if applicable
