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[25] It can be administered by subcutaneous injection or taken orally

Abcam, Cambridge, UK) and mouse monoclonal anti-glucagon antibody (1:100 dilution, Sigma)

This means it works differently from GLP-1-only medicines and dual agonist medicines

Authors contributions NG, AD and GF designed the study

Retatrutide Activates GIP, GLP-1, and Glucagon Receptors Research suggests retatrutide functions as: A GLP-1 receptor agonist A glucagon receptor agonist A glucose-dependent insulinotropic polypeptide receptor agonist This multi-pathway receptor activity may influence: Glucose metabolism Energy expenditure Appetite signaling Glycemic control Endocrine pathways Overall metabolic regulation Retatrutide also activates GIP receptor pathways that researchers believe may contribute to improved metabolic signaling and weight management outcomes

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