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N/A (chimeric research peptide) AOD-9604 Mol
In EAE mice, adoptive transfer of itaconate-treated, Th17-polarized T cells significantly ameliorated disease severity (173), highlighting the potential of targeting metabolic pathways to modulate the Th17/Treg balance in autoimmune neuroinflammation
Continuous variables with skewed distribution were expressed as medians (interquartile range) and compared using the Wilcoxon rank-sum test
Cellular iron uptake is primarily mediated by the transferrin receptor
Excessive H 2 O 2 reacts with Fe 2+ via Fenton chemistry, yielding highly toxic hydroxyl radicals, culminating in lipid peroxidation and apoptosis of nigral neurons
AOD-9604 is proposed to support fat mobilization / reduce fat storage signaling
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