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Elevated levels of reactive oxygen species can activate pro-inflammatory signaling cascades and apoptotic pathways, which in turn exacerbate neuroinflammation, impair neurogenesis, and contribute to synaptic and structural changes implicated in depression (104)

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Compared to pioglitazone treatment, rosiglitazone increases the risk of AMI and heart failure in type 2 diabetic patients and elderly patients [222,223,224]

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Unlike minoxidil, it addresses the structural environment of the follicle rather than blood flow alone