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The mechanism involves activating the pituitary gland through pathways like protein kinase C (PKC) and phospholipase C (PLC), which promotes the release of growth hormone (GH) into the bloodstream

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Consistently, the livers of HFD-fed mice showed increased IKK--SSG levels, decreased IKK- phosphorylation, and suppressed NF-B activation when compared to these from control animals