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The mixed results emphasize the need for further research to determine how GLP-1 medications may be used to treat OUD and other substance use disorders

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New evidence suggests trizepatide (Zepound/Mounjaro) produces the largest weight loss on average, outperforming semaglutide in trials

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This shift from a single observation of a plasma factor toward a gene expression modulator profile defines much of the contemporary literature on this tripeptide

Tirzepatide (Mounjaro/Zepbound) is a dual GIP/GLP-1 receptor agonist that has shown even greater weight loss than semaglutide in head-to-head trials