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Some patients report feeling colder while taking Zepbound due to metabolic changes, fat loss, reduced calorie intake, and altered circulation rather than direct temperature dysregulation, and Trim Body M.D

Any individual with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN 2) should not take this medication

In this context, the consideration of dose-dependent side effects, such as exacerbating breathing difficulties in obstructive sleep apnea patients, impaired blood glucose control when consumed with carbohydrate-rich meals, and an increased risk of nighttime falls due to drowsiness, especially in the elderly, is imperative [236,237,238]

Personal response varies substantially

10.1021/jf049436e 94 GreseleP.PignatelliP.GuglielminiG.CarnevaleR.MezzasomaA

J Venom Anim Toxins Incl Trop Dis 29:e20230029