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The digestive tract wall is selectively permeable

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Beyond Barriers is confident the results will be more robust when delivered intranasally. Using a repurposed drug lets the company pursue the 505(b)(2) FDA approval pathway, which Kole says, has a three-fold better chance of success of approval than the traditional 505(b)(1) route and is less expensive and time-intensive. Administration doses and schedules are to be determined, but early research suggests the administration window may be as long as 72 hours after injury

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In summary, the synthesis of PT-141 is a relatively complex process that requires strict control of reaction conditions and raw material quality, as well as attention to safety issues