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An injection delivers B12 directly into the muscle, so absorption does not depend on your digestive system

Studies comparing localized versus systemic delivery for other biologics (botulinum toxin, platelet-rich plasma) suggest systemic routes produce more uniform results across larger treatment areas

2 People assigned female at birth generally have a higher percentage of body fat, lower levels of water in the body, and less of the enzyme that breaks down alcohol, compared to people assigned male at birth

Systemic effects including cognitive benefits, mood regulation, and general tissue maintenance could work with either route, though injection delivers more predictable exposure levels

A doctor can usually narrow down the cause based on where the symptoms are, how they started, and whether they're progressing