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Unexplained anemia: Particularly in a specific form (megaloblastic anemia) where the red blood cells are enlarged, a vitamin B12 deficiency is a common cause

1 2 Current Opinion in Plant Biology

If your digestive system isn't working properly, oral supplements can be ineffective

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People older than 50 should get most of their vitamin B12 from supplements because they often don't have enough stomach acid to absorb it from food efficiently

Vitamin B12 shots are usually deep intramuscular injections every 2-3 months in large muscles