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Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin

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NNMT is overexpressed in select tissues (e.g., adipose tissue, skeletal muscle, etc.) in pathophysiological conditions, making it a clinically relevant target for drug development in several chronic diseases including obesity and diabetes

10.1186/s13046-018-0750-752 J

Many researchers describe this as the phase where caloric intake reductions become genuinely effortless rather than something requiring active management

* These therapies are not FDA approved for the treatment, cure, or prevention of any disease