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As ECM stiffness increases, mechanotransduction through integrins further enhances fibroblast activation and phenotypic transformation, acting synergistically with TGF-1 (128, 129)

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Although there is a robust heat shock response of Hsp70 in endometriosis (117), ROS damages heat shock proteins impeding HSP-mediated re-folding of polypeptides misfolded and otherwise damaged due to oxidative stress

Flanagan E, Wright EK, Begun J, et al