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At 12mg weekly, trials show 24.2% weight loss at 48 weeks and up to 28.7% at 68 weeks in Phase 3

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One of the illustrious challenges lies in constituting directionality and causality in the gut-brain axis, as the bidirectional exchange of information between these systems makes it complex to specifically determine whether the modulations in the microbiota composition are the main cause or consequence of depression disorder

Huang X, Zhang Y, Jiang Y, Li T, Yang S, Wang Y et al (2024) Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration