Phosphorylation of eIF2 leads to inhibition of general protein synthesis, but paradoxically increases the translation of selective mRNA such as ATF4 16
Figure 6 Figure 7 3.3 NLRs and inflammasomes NLRs play crucial roles not only in sensing PAMPs and DAMPs but also in detecting disturbances in cellular homeostasis, such as redox imbalance, ion flux, and other forms of cellular stress (57)
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167169 This notion of flexibility as interconversion between conformations is critical for understanding biological processes and their regulation, such as protein activation as a shift of the ensemble from the inactive to the active state, how allosteric drugs work, cell signaling, and binding mechanisms through conformational selection rather than induced fit
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